TP53

Type

Gene (protein-coding, tumor suppressor)

Description

TP53 encodes the p53 tumor suppressor protein, the most frequently mutated gene in human cancer. p53 functions as a transcription factor that regulates cell cycle arrest, apoptosis, DNA repair, and senescence in response to cellular stress. Loss of TP53 function — through mutation or deletion — is a hallmark driver event in the majority of cancer types. TP53 mutation status is associated with genomic instability, chromothripsis, and whole-genome doubling.

External identifiers

• HGNC: 11998
• NCBI Gene: 7157
• UniProt: P04637

Wiki sources

• pcawg2020-pan-cancer-analysis — Pan-cancer driver catalog; TP53 among most frequently mutated
• gerstung2020-evolutionary-history-cancer — TP53 mutations in early clonal evolution across cancer types
• turajlic2019-genetic-heterogeneity-cancer — TP53 loss and chromosomal instability