Prostate Cancer

Type

Cancer type

Description

Prostate cancer is an androgen-driven malignancy and the second most common cancer in men worldwide. It is characterized by AR-dependent growth, with androgen deprivation therapy (ADT) as the mainstay treatment. Metastatic prostate cancer exhibits recurrent intratumor heterogeneity with transcriptional plasticity enabling AR-independent survival. Key genes include AR (androgen receptor), FOLH1/PSMA, and transcription factors driving lineage plasticity (AP-1, CTCFL, KLK). Metastatic dissemination patterns include both monophyletic and polyphyletic seeding.

Wiki sources

• weng2026-ith-prostate-cancer — Recurrent ITH and transcriptional heterogeneity in metastatic prostate cancer
• mikutenaite2025-clonal-evolution-transcriptional-plasticity — Clonal evolution and transcriptional plasticity in prostate cancer metastasis