Lung Cancer

Type

Cancer type

Description

Lung cancer is the leading cause of cancer death worldwide. The two major histological subtypes are non-small cell lung cancer (NSCLC, ~85%) and small cell lung cancer (SCLC, ~15%). NSCLC subtypes include lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC). The TRACERx study established ctDNA-based phylogenetic tracking as a method for monitoring subclonal evolution in NSCLC. LUAD is driven by mutations in EGFR, KRAS, and other oncogenes; LUSC is more strongly associated with smoking and APOBEC mutagenesis.

Wiki sources

• abbosh2017-ctdna-tracerx — Phylogenetic ctDNA analysis in early-stage NSCLC
• bakir2023-tracerx-metastasis — Metastatic dissemination patterns in TRACERx
• pcawg2020-pan-cancer-analysis — Pan-cancer analysis