EGFR

Type

Gene (protein-coding, receptor tyrosine kinase)

Description

EGFR (Epidermal Growth Factor Receptor) encodes a transmembrane receptor tyrosine kinase that regulates cell proliferation, survival, and differentiation. Activating mutations and amplifications in EGFR are driver events in non-small cell lung cancer (particularly adenocarcinoma) and other cancers. EGFR mutation status is a key biomarker for tyrosine kinase inhibitor (TKI) therapy selection and is frequently monitored via ctDNA for treatment response and resistance emergence.

External identifiers

• HGNC: 3236
• NCBI Gene: 1956
• UniProt: P00533

Wiki sources

• abbosh2017-ctdna-tracerx — ctDNA detection of EGFR mutations in NSCLC
• pcawg2020-pan-cancer-analysis — Pan-cancer driver catalog
• wander2026-ctdna-cdk46-breast-cancer — ctDNA monitoring of therapy resistance