Colorectal Cancer

Type

Cancer type

Description

Colorectal cancer (CRC) is the third most common cancer worldwide. It is a well-established model for studying clonal evolution due to its stepwise adenoma-carcinoma sequence and well-characterized driver mutations (APC, KRAS, TP53, SMAD4). Metastatic CRC exhibits clonal evolution shaped by anticancer therapies, with distinct mutational trajectories between primary and metastatic sites.

Wiki sources

• lee2026-clonal-evolution-crc — Clonal evolution and mutational trajectories of metastatic CRC under therapy
• pcawg2020-pan-cancer-analysis — Pan-cancer analysis