Breast Cancer

Type

Cancer type

Description

Breast cancer is the most studied cancer type in the wiki’s corpus. It is the cancer in which APOBEC mutagenesis was first characterized (Nik-Zainal et al., 2012) and in which APOBEC3B was first identified as a mutator (Burns et al., 2013). Key molecular subtypes include HR+/HER2- (luminal), HER2+, and triple-negative. HR+ breast cancer is treated with endocrine therapy (aromatase inhibitors, SERDs) and CDK4/6 inhibitors; resistance mutations in ESR1, RB1, and PIK3CA are detectable via ctDNA.

Wiki sources

• burns2014-apobec3b-pathological-consequences — APOBEC3B identified as mutator in breast cancer
• nik-zainal2012-21-breast-cancers — Mutational processes in 21 breast cancer genomes
• pcawg2020-pan-cancer-analysis — Pan-cancer analysis including breast cancer
• wander2026-ctdna-cdk46-breast-cancer — ctDNA monitoring of CDK4/6 inhibitor resistance in HR+ breast cancer