AR

Type

Gene (protein-coding, hormone receptor)

Description

AR (Androgen Receptor) encodes a ligand-activated transcription factor that is the central driver of prostate cancer. Androgen deprivation therapy (ADT) targets AR signaling, but resistance universally emerges through mechanisms including AR amplification, AR mutations, constitutively active AR splice variants (e.g., AR-V7), and glucocorticoid receptor bypass. AR-driven transcriptional programs are a major source of phenotypic plasticity in metastatic prostate cancer.

External identifiers

• HGNC: 644
• NCBI Gene: 367
• UniProt: P10275

Wiki sources

• weng2026-ith-prostate-cancer — Recurrent ITH in metastatic prostate cancer; AR-driven heterogeneity
• mikutenaite2025-clonal-evolution-transcriptional-plasticity — Transcriptional plasticity and AR independence in prostate cancer metastasis